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bioRxiv · 10.1101/2022.04.10.487568

TIGER: A Web Portal of Tumor Immunotherapy Gene Expression Resource

chen, z.·Luo, Z.·Zhang, D.·Li, H.·Liu, X.·Zhu, K.·Zhang, H.·Wang, Z.·Zhou, P.·Ren, J.·Zhao, A.·Zuo, Z.
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Abstract

Immunotherapy is a promising cancer treatment method, but only a few patients benefit from it. Developing new immunotherapy strategies and effective biomarkers of response and resistance is urgent. Recent high-throughput bulk and single-cell gene expression profiling technologies have generated valuable resources in these regards. However, these resources are not well organized and systematic analysis is difficult. Here, we present TIGER, a tumor immunotherapy gene expression resource, which contains bulk transcriptome data of 1508 tumor samples with immunotherapy clinical outcome and 11,057 tumor/normal samples without immunotherapy clinical outcome, as well as single-cell transcriptome data of 2,116,945 immune cells of 655 samples. TIGER provides many useful modules to analyze the collected data and user-provided data. Using the resource in TIGER, we identified a tumor enriched subset of CD4+ T cells. Melanoma patients with higher signature score of this subset have significantly better response and survival under immunotherapy. We believe that TIGER will be helpful for understanding anti-tumor immunity mechanisms and discovering effective biomarkers. TIGER is freely accessible at http://tiger.canceromics.org/.

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chen, z., Luo, Z., Zhang, D., Li, H., Liu, X., Zhu, K., Zhang, H., Wang, Z., Zhou, P., Ren, J., Zhao, A., Zuo, Z.. 2022-04-10. TIGER: A Web Portal of Tumor Immunotherapy Gene Expression Resource. https://doi.org/10.1101/2022.04.10.487568

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