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bioRxiv · 10.1101/2022.04.04.486960

A computational modeling of primary-microRNA expression

Zheng, H.·Wang, S.·Li, X.·Hu, H.
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Abstract

MicroRNAs (miRNAs) play crucial roles in gene regulation. Most studies so far focus on mature miRNAs, which leaves many gaps in our knowledge in primary miRNAs (pri-miRNA). To fill these gaps, we attempted to model the expression of pri-miRNAs in 1829 primary cell types and tissues in this study. We demonstrated that the expression of their associated mRNAs could model the expression of the pri-miRNAs well. These associated mRNAs are different from their corresponding target mRNAs and are enriched with specific functions. The majority of the associated mRNAs of a miRNA are shared across conditions, although a fraction of the associated mRNAs are condition-specific. Our study shed new light on the understanding of miRNA biogenesis and general gene transcriptional regulation.

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Zheng, H., Wang, S., Li, X., Hu, H.. 2022-04-05. A computational modeling of primary-microRNA expression. https://doi.org/10.1101/2022.04.04.486960

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