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bioRxiv · 10.1101/2022.04.01.486723

Inter-Individual Variability in Dorsal Stream Dynamics During Word Production

Abstract

The current standard model of language production involves a sensorimotor dorsal stream connecting areas in the temporo-parietal junction with those in the inferior frontal gyrus and lateral premotor cortex. These regions have been linked to various aspects of word production such as phonological processing or articulatory programming, primarily through neuropsychological and functional imaging group studies. Most if not all the theoretical descriptions of this model imply that the same network should be identifiable across individual speakers. We tested this hypothesis by quantifying the variability of activation observed across individuals within each dorsal stream anatomical region. This estimate was based on electrical activity recorded directly from the cerebral cortex with millisecond accuracy in awake epileptic patients clinically implanted with intracerebral depth electrodes for pre-surgical diagnosis. Each regions activity was quantified using two different metrics--intra-cerebral evoked related potentials and high gamma activity--at the level of the group, the individual, and the recording contact. Using picture naming task, the two metrics show simultaneous activation of parietal and frontal regions in line with models that posit interactive processing during word retrieval. They also reveal different levels of variability across brain regions and patients except in auditory and motor regions. The independence and non-uniformity of cortical activity according to the two metrics push the current model towards sub-second and sub-region explorations focused on individualized language speech production. Several hypotheses are considered for this within-region heterogeneity.

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BibTeXRIS

Liegeois-Chauvel, C., Dubarry, A.-S., Wang, I. Z., Chauvel, P., Gonzalez-Martinez, J., Alario, F.- X.. 2022-04-02. Inter-Individual Variability in Dorsal Stream Dynamics During Word Production. https://doi.org/10.1101/2022.04.01.486723

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