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bioRxiv · 10.1101/2022.03.30.486409

Cross neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

Zou, J.·Kurhade, C.·Xia, H.·Liu, M.·Xie, X.·Ren, P.·Shi, P.-Y.
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Abstract

The Omicron SARS-CoV-2 has three distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 world-wide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we tested the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralized BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 were 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.

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Zou, J., Kurhade, C., Xia, H., Liu, M., Xie, X., Ren, P., Shi, P.-Y.. 2022-03-31. Cross neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2. https://doi.org/10.1101/2022.03.30.486409

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