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bioRxiv · 10.1101/2022.03.26.485917

T cells induce interferon-responsive oligodendrocytes during white matter aging

Kaya, T.·Mattugini, N.·Liu, L.·Ji, H.·Besson-Girard, S.·Kaji, S.·Liesz, A.·Gokce, O.·Simons, M.
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Abstract

A hallmark of nervous system aging is a decline of white matter volume and function, but the underlying mechanisms leading to white matter pathology are unknown. Here, we found age-related alterations of oligodendrocytes with a reduction of total oligodendrocyte density in the aging murine white matter. Using single-cell RNA sequencing, we identify interferon-responsive oligodendrocytes, which localize in proximity of CD8+ T cells in the aging white matter. Absence of functional lymphocytes decreased oligodendrocyte reactivity and rescued oligodendrocyte loss, while T-cell checkpoint inhibition worsened the aging affect. In summary, we provide evidence that T cells induced interferon-responsive oligodendrocytes are important modifiers of white matter aging.

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Kaya, T., Mattugini, N., Liu, L., Ji, H., Besson-Girard, S., Kaji, S., Liesz, A., Gokce, O., Simons, M.. 2022-03-27. T cells induce interferon-responsive oligodendrocytes during white matter aging. https://doi.org/10.1101/2022.03.26.485917

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