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bioRxiv · 10.1101/2022.03.22.485315

flashfm-ivis: interactive visualisation for fine-mapping of multiple quantitative traits

Zhou, F.·Butterworth, A. S.·Asimit, J. L.
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Abstract

Summaryflashfm-ivis provides a suite of interactive visualisation plots to view potential causal genetic variants that underlie associations that are shared or distinct between multiple quantitative traits and compares results between single- and multi-trait fine-mapping. Unique features include network diagrams that show joint effects between variants for each trait and regional association plots that integrate fine-mapping results, all with user-controlled zoom features for an interactive exploration of potential causal variants across traits. Availability and Implementationflashfm-ivis is an open-source software under the MIT license. It is available as an interactive web-based tool (http://shiny.mrc-bsu.cam.ac.uk/apps/flashfm-ivis/) and as an R package format. Code and documentation are available at https://github.com/fz-cambridge/flashfm-ivis and https://zenodo.org/record/6376244#.YjnarC-l2X0. Additional features can be downloaded as standalone R libraries to encourage reuse. Contactfeng.zhou@mrc-bsu.cam.ac.uk or jennifer.asimit@mrc-bsu.cam.ac.uk

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Zhou, F., Butterworth, A. S., Asimit, J. L.. 2022-03-25. flashfm-ivis: interactive visualisation for fine-mapping of multiple quantitative traits. https://doi.org/10.1101/2022.03.22.485315

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