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bioRxiv · 10.1101/2022.03.21.485094

CROSS-GENERATIONAL IMPACT OF EPIGENETIC MALE INFLUENCE ON PHYSICAL ACTIVITY IN RAT

Sudakov, S. K.·Bogdanova, N. G.·Nazarova, G. K.
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Abstract

The aim of this work was to study whether epigenetic events at conception influence the formation of behavioral features found in adult rats. First generational inheritance of activity level, anxiety, and learning ability was studied. To separate genetic and non-genetic inheritance, mating of males and females with average motor activity was carried out in the presence males with high or low activity. Our results show that offspring of parents who mated in the presence of males with a high motor activity were significantly more active than offspring of parents that were paired in the presence of males with low activity. Anxiety level and learning ability were not inherited in this way. It is possible that the phenomenon we discovered is important for maintaining a certain level of activity of specific populations of animals. It counteracts natural selection, which should lead to a constant increase in the activity of animals.

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Sudakov, S. K., Bogdanova, N. G., Nazarova, G. K.. 2022-03-21. CROSS-GENERATIONAL IMPACT OF EPIGENETIC MALE INFLUENCE ON PHYSICAL ACTIVITY IN RAT. https://doi.org/10.1101/2022.03.21.485094

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