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bioRxiv · 10.1101/2022.02.25.481997

Adenosine A2A Receptor (A2AR) agonists improve survival in K28-hACE2 mice following SARS CoV-2 infection

Mann, B. J.·Chhabra, P.·Ma, M.·Brovero, S. G.·Jones, M. K.·Linden, J. M.·Brayman, K. L.
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Abstract

Effective and available therapies for the treatment of COVID-19 disease are limited. Apadenoson is a highly potent selective anti-inflammatory adenosine A2A receptor (A2AR) agonist and potential treatment option for COVID-19 patients. Apadenoson, when administered after infection with SARS CoV-2, was found to decrease weight loss, improve clinical symptoms, reduce levels of a several proinflammatory cytokines and chemokines in bronchial lavage (BAL) fluid, and promote increased survival in K18hACE2 transgenic mice. Of note, administering apadenoson after, but not prior to Covid-19 infection, caused a rapid decrease in lung viral burden. The work presented provides the foundation for further examination of these drugs as a therapy option for COVID-19. SummaryApadenoson therapy improves COVID-19 outcome

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Mann, B. J., Chhabra, P., Ma, M., Brovero, S. G., Jones, M. K., Linden, J. M., Brayman, K. L.. 2022-02-26. Adenosine A2A Receptor (A2AR) agonists improve survival in K28-hACE2 mice following SARS CoV-2 infection. https://doi.org/10.1101/2022.02.25.481997

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