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bioRxiv · 10.1101/2022.02.21.481321

Response dynamics of spiking network models to incoming seizure-like perturbation.

Abstract

Epilepsies are characterized by paroxysmal electrophysiological events and seizures, which can propagate across the brain. One of the main unsolved questions in epilepsy is how epileptic activity can invade normal tissue and thus propagate across the brain. To investigate this question, we propose three computational models at the neural network scale to study the underlying dynamics of seizure propagation, understand which specific features play a role, and relate them to clinical or experimental observations. We consider both the internal connectivity structure between neurons and the input properties in our characterization. We show that a paroxysmal input is sometimes controlled by the network while in other instances, it can entrain the network activity to itself produce paroxysmal activity, and thus will further propagate to efferent networks. We further show how the details of the network architecture are essential to determine this switch to a seizure-like regime. We investigated the nature of the instability involved and in particular found a central role for the inhibitory connectivity. We propose a probabilistic approach to the propagative/non-propagative scenarios, which may serve as a guide to control the seizure by using appropriate stimuli. SignificanceOur computational study shows the specific role that the inhibitory population can have and the possible dynamics regarding the propagation of seizure-like behavior in three different neuronal networks. We find that both structural and dynamical aspects are important to determine whether seizure activity invades the network. We show the existence of a specific time window favorable to the reversal of the seizure propagation by appropriate stimuli.

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BibTeXRIS

Depannemaecker, D., Carlu, M., Destexhe, A.. 2022-02-22. Response dynamics of spiking network models to incoming seizure-like perturbation.. https://doi.org/10.1101/2022.02.21.481321

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