Experience-dependent learning and myelin plasticity in individuals with stroke

Rubino, C.; Larssen, B. C.; Chiu, L. K.; Liu, H.; Kraeutner, S. N.; Mahendran, N.; Denyer, R.; Lakhani, B.; Borich, M. R.; Cornelia, L.; Boyd, L. A.

doi:10.1101/2022.02.17.480894

bioRxiv · 10.1101/2022.02.17.480894

Experience-dependent learning and myelin plasticity in individuals with stroke

Rubino, C.·Larssen, B. C.·Chiu, L. K.·Liu, H.·Kraeutner, S. N.·Mahendran, N.·Denyer, R.·Lakhani, B.·Borich, M. R.·Cornelia, L.·Boyd, L. A.

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Abstract

BackgroundInjury to brain myelin disrupts motor performance and learning, however it is not clear if myelination is modulated by skilled motor practice or by recovery after stroke. Multi-component relaxation imaging can be used to measure water trapped between myelin bilayers which is expressed as myelin water fraction. The purpose of this study was to examine the effect of experience-dependent learning on myelin plasticity using multi-component relaxation imaging in individuals with stroke. MethodsThirty-two individuals with chronic stroke (>6 months) and twenty-seven healthy controls completed 4 weeks of skilled motor practice using a complex, gamified reaching task. Multi-component relaxation imaging-derived myelin water fraction was obtained before and after training. Seven brain regions associated with motor learning and sensorimotor function were investigated. ResultsAll participants improved task-specific reaching movements after training. In individuals with stroke: 1) pre-training myelin water fraction was lower in motor brain regions but higher in the cingulum compared to controls, 2) pre-training myelin water fraction in motor and sensorimotor regions was positively associated with learning rate, and 3) myelin water fraction was increased in the ipsilesional (contralateral to the trained arm) superior longitudinal fasciculus following skilled motor practice. ConclusionsFindings indicate that after stroke, myelin water fraction is related to measures of motor learning and modulated by 4 weeks of skilled motor practice with the paretic limb. Myelin water fraction can be enhanced in the chronic stage of stroke and may be an important target for upper-limb motor recovery.

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Rubino, C., Larssen, B. C., Chiu, L. K., Liu, H., Kraeutner, S. N., Mahendran, N., Denyer, R., Lakhani, B., Borich, M. R., Cornelia, L., Boyd, L. A.. 2022-02-19. Experience-dependent learning and myelin plasticity in individuals with stroke. https://doi.org/10.1101/2022.02.17.480894

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