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bioRxiv · 10.1101/2022.02.10.478818

Photolabile curcumin with physically and molecularly produced light for attenuating of neurotoxicity of amyloid beta species

Kuang, S.·Zhu, B.·Zhang, J.·Yang, F.·Wu, B.·Ran, C.
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Abstract

Over the past decades, classical drug development approaches for Alzheimers disease have yielded limited success, and this futileness has prompted scientists to seek non-classical approaches. In this report, we demonstrated that, with irradiation of LED light or with molecularly generated light (dubbed as "molecular light") from chemiluminescence probe ADLumin-4, photolabile curcumin analogue CRANAD-147 could change properties, structures (sequences) and neurotoxicity of amyloid beta (A{beta}) species in vitro. We further demonstrated that, with the assistance from molecular chemiluminescence imaging, the combination of CRANAD-147/LED or CRANAD-147/ADLumin-4 (molecular light) could slow down the accumulation of A{beta}s in transgenic 5xFAD mice in vivo. Due to the unlimited capacity of tissue penetration of molecular light in vivo, phototherapy with the combination of photolabile A{beta} ligand and molecular light has great potential as an alternative approach for AD drug discovery.

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Kuang, S., Zhu, B., Zhang, J., Yang, F., Wu, B., Ran, C.. 2022-02-11. Photolabile curcumin with physically and molecularly produced light for attenuating of neurotoxicity of amyloid beta species. https://doi.org/10.1101/2022.02.10.478818

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