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bioRxiv · 10.1101/2022.02.03.479080

In vitro effect of a non-immunosuppressive FKBP ligand, FK1706, on SARS-CoV-2 replication in combination with antivirals

Fitzsimmons, W.·Chen, C.·Mendenhall, M.·Hartman, T. L.
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Abstract

FKBP, a naturally occurring ubiquitous intracellular protein, has been proposed as a potential target for coronavirus replication. A non-immunosuppressive FKBP ligand, FK1706, was studied in vitro in a Vero cell model to assess potential activity alone and in combination with antivirals against SARS-CoV-2 replication. When combined with remdesivir, synergistic activity was seen (summary synergy score 24.7+9.56). FK1706 warrants in vivo testing as a potential new combination therapeutic for the treatment of COVID-19 infections.

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Fitzsimmons, W., Chen, C., Mendenhall, M., Hartman, T. L.. 2022-02-04. In vitro effect of a non-immunosuppressive FKBP ligand, FK1706, on SARS-CoV-2 replication in combination with antivirals. https://doi.org/10.1101/2022.02.03.479080

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