Single-cell transcriptomics of dynamic cell behaviors

Vinarsky, V.; Haber, A.; Kwok, S. J.; Yun, S.-H.; Montoro, D. T.

doi:10.1101/2022.01.31.478519

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bioRxiv · 10.1101/2022.01.31.478519

Single-cell transcriptomics of dynamic cell behaviors

Vinarsky, V.·Haber, A.·Kwok, S. J.·Yun, S.-H.·Montoro, D. T.

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Abstract

Despite advances in spatial transcriptomics, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method, termed behavioral transcriptomics, that allows us to couple physiological behaviors of single cells in an intact tissue to deep molecular profiling of individual cells. This method enabled us to establish a novel molecular signature for a striking migratory cellular behavior following tissue injury.

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Vinarsky, V., Haber, A., Kwok, S. J., Yun, S.-H., Montoro, D. T.. 2022-01-31. Single-cell transcriptomics of dynamic cell behaviors. https://doi.org/10.1101/2022.01.31.478519

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