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bioRxiv · 10.1101/2022.01.30.478181

Vamos en bici: Study protocol of an investigation of cognitive and neural changes following language training, physical exercise training, or a combination of both

Wenger, E.·Duezel, S.·Polk, S. E.·Bodammer, N. C.·Misgeld, C.·Porst, J.·Wolfarth, B.·Kuehn, S.·Lindenberger, U.
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Abstract

As the relative number of elderly people as well as the average life expectancy increases, identifying potential means to alter the ongoing trajectory of aging and specifically the trajectory of cognitive performance is of great importance. Some modifiable lifestyle factors, such as physical and cognitive activity, have shown positive effects on cognition and brain structure, and the combination of the two might even show a boosted, interactive effect. In this study protocol, we describe in detail our data which was acquired to explore how cognitive stimulation in the form of acquiring a new language, physical exercise on stationary bikes or the combination of the two interventions affect brain structure, cognitive performance, and psychosocial functioning. One-hundred and forty-two older healthy adults (63-78 years) were randomly assigned to one of four six-month intervention programs, comprising (a) foreign language learning, (b) physical exercise training on a bicycle ergometer, (c) a combination of language learning and physical exercise, or (d) a book club (serving as an active control condition). We collected a rich neuroimaging data set, comprising T1-weighted structural, resting state functional, high resolution hippocampal, myelin water fraction, diffusion-weighted, arterial spin labeling, and multi-parameter images. Using a cognitive battery, we collected data from the domains of episodic memory, working memory, perceptual speed, and fluid intelligence. We performed comprehensive physical assessments including cardiopulmonary exercise testing, and additionally collected data on psychosocial functioning (e.g., well-being, perceived stress, control beliefs). We assume that physical activity boosts brain plasticity per se by inducing structural and neurochemical changes in brain regions that are important for learning and memory and therefore may facilitate the effects of cognitive training. (269 words)

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Wenger, E., Duezel, S., Polk, S. E., Bodammer, N. C., Misgeld, C., Porst, J., Wolfarth, B., Kuehn, S., Lindenberger, U.. 2022-01-31. Vamos en bici: Study protocol of an investigation of cognitive and neural changes following language training, physical exercise training, or a combination of both. https://doi.org/10.1101/2022.01.30.478181

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