The propensity to sign-track is associated with externalizing behaviour and distinct patterns of reward-related brain activation in youth

Abstract

Externalizing behaviours in childhood often predict impulse control disorders in adulthood; however, the underlying biobehavioural risk factors are incompletely understood. In animals, the propensity to signtrack, or the degree to which incentive motivational value is attributed to reward cues, is associated with externalizing-type behaviours and deficits in executive control. Using a Pavlovian conditioned approach paradigm, we quantified sign-tracking in healthy 9-12-year-olds. We also measured parent-reported externalizing behaviours and anticipatory neural activations to outcome-predicting cues using the monetary incentive delay fMRI task. Sign-tracking was associated with attentional and inhibitory control deficits and the degree of amygdala, but not cortical, activation during reward anticipation. These findings support the hypothesis that youth with a propensity to sign-track are prone to externalizing tendencies, with an over-reliance on subcortical cue-reactive brain systems. This research highlights sign-tracking as a promising experimental approach delineating the behavioural and neural circuitry of individuals at risk for externalizing disorders.