Latent circuit inference from heterogeneous neural responses during cognitive tasks

Abstract

Higher cortical areas carry a wide range of sensory, cognitive, and motor signals supporting complex goal-directed behavior. These signals are mixed in heterogeneous responses of single neurons tuned to multiple task variables. Dimensionality reduction methods used to analyze neural responses rely merely on correlations, leaving unknown how heterogeneous neural activity arises from connectivity to drive behavior. Here we present a framework for inferring a low-dimensional connectivity structure--the latent circuit--from high-dimensional neural response data. The latent circuit captures mechanistic interactions between task variables and their mixed representations in single neurons. We apply the latent circuit inference to recurrent neural networks trained to perform a context-dependent decision-making task and find a suppression mechanism in which contextual representations inhibit irrelevant sensory responses. We validate this mechanism by confirming the behavioral effects of patterned connectivity perturbations predicted by the latent circuit structure. Our approach can reveal interpretable and causally testable circuit mechanisms from heterogeneous neural responses during cognitive tasks.