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bioRxiv · 10.1101/2022.01.21.477184

Genetic control of neuronal activity enhances axonal growth only on permissive substrates

Mesquida-Veny, F.·Martinez-Torres, S.·del Rio, J. A.·Hervera Abad, A.
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Abstract

Neural tissue has limited regenerative ability, to cope with that, in the recent years a diverse set of novel tools have been used to tailor neurostimulation therapies and promote functional regeneration after axonal injuries. In this report, we explore cell-specific methods to modulate neuronal activity, including opto- and chemogenetics to assess the effect of specific neuronal stimulation in the promotion of axonal regeneration after injury. We found that opto- or chemogenetic modulations of neuronal activity on both dorsal root ganglia and corticospinal motor neurons increase their axonal growth capacity only on permissive substrates.

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Mesquida-Veny, F., Martinez-Torres, S., del Rio, J. A., Hervera Abad, A.. 2022-01-23. Genetic control of neuronal activity enhances axonal growth only on permissive substrates. https://doi.org/10.1101/2022.01.21.477184

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