GNN-SubNet: disease subnetwork detection with explainable Graph Neural Networks

Pfeifer, B.; Secic, A.; Saranti, A.; Holzinger, A.

doi:10.1101/2022.01.12.475995

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bioRxiv · 10.1101/2022.01.12.475995

GNN-SubNet: disease subnetwork detection with explainable Graph Neural Networks

Pfeifer, B.·Secic, A.·Saranti, A.·Holzinger, A.

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Abstract

The tremendous success of graphical neural networks (GNNs) has already had a major impact on systems biology research. For example, GNNs are currently used for drug target recognition in protein-drug interaction networks as well as cancer gene discovery and more. Important aspects whose practical relevance is often underestimated are comprehensibility, interpretability, and explainability. In this work, we present a graph-based deep learning framework for disease subnetwork detection via explainable GNNs. In our framework, each patient is represented by the topology of a protein-protein network (PPI), and the nodes are enriched by molecular multimodal data, such as gene expression and DNA methylation. Therefore, our novel modification of the GNNexplainer for model-wide explanations can detect potential disease subnetworks, which is of high practical relevance. The proposed methods are implemented in the GNN-SubNet Python program, which we have made freely available on our GitHub for the international research community (https://github.com/pievos101/GNN-SubNet).

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Pfeifer, B., Secic, A., Saranti, A., Holzinger, A.. 2022-01-12. GNN-SubNet: disease subnetwork detection with explainable Graph Neural Networks. https://doi.org/10.1101/2022.01.12.475995

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