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bioRxiv · 10.1101/2022.01.04.474923

Cost-effectiveness of quadrivalent versus trivalent inactivated influenza vaccines for the Portuguese elderly population

Tavares, D.·Mourino, H.·Rodriguez, C. A.·Saborido, C. M.
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Abstract

BackgroundQuadrivalent Inactivated Vaccine (QIV) is expected to replace Trivalent Inactivated Vaccine (TIV) over time. In Portugal, TIV is free of charge for risk groups, which include older adults. In its turn, QIV - which provides broader protection as it includes an additional lineage B strain - was introduced in Portugal in October 2018, but only from the influenza season 2019/20 was provided free of charge for the risk groups. This study evaluates the cost-effectiveness of switching from TIV to QIV from the National Health Service perspective in the Portuguese elderly mainland population ([≥] 65 years old). MethodsA decision tree model was developed to compare TIV and QIV, based on Portuguese hospitalization data for the 2015/16 influenza season. The primary health economic outcome under consideration was the Incremental Cost-Effectiveness Ratio (ICER). In addition, a one-Way Sensitivity Analysis was performed to evaluate the impact of model parameters on the ICER; Probabilistic Sensitivity Analysis was also carried out to analyze the robustness of the base case results. ResultsThe high cost of QIV (approximately three times the cost of TIV) would lead to a total increment of 5,283,047 {euro}, and the resulting ICER would be 26,403,007{euro}/QALY, mainly above the usual willingness-to-pay threshold. ConclusionsFrom the National Health Service perspective, our findings reveal that QIV is not cost-effective for the Portuguese elderly population due to the high cost. If the QIV costs were the same as the TIV, then QIV would be cost-effective.

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Tavares, D., Mourino, H., Rodriguez, C. A., Saborido, C. M.. 2022-01-04. Cost-effectiveness of quadrivalent versus trivalent inactivated influenza vaccines for the Portuguese elderly population. https://doi.org/10.1101/2022.01.04.474923

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