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bioRxiv · 10.1101/2021.12.22.473938

An analytical solution simulating growth of Lewy bodies

Kuznetsov, I. A.·Kuznetsov, A. V.
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Abstract

This paper reports a minimal model simulating the growth of a Lewy body (LB). To the best of our knowledge, this is the first model simulating Lewy body growth. The LB is assumed to consist of a central spherical core, which is composed of membrane fragments and various dysfunctional intracellular organelles, and a halo, which is composed of alpha-synuclein fibrils. Membrane fragments and alpha-synuclein monomers are assumed to be produced in the soma at constant rates. The growth of the core and the halo are simulated by the Finke-Watzky model. Analytical (closed-form) solutions describing the growth of the core and the halo are obtained. A sensitivity analysis in terms of model parameters is performed.

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Kuznetsov, I. A., Kuznetsov, A. V.. 2021-12-23. An analytical solution simulating growth of Lewy bodies. https://doi.org/10.1101/2021.12.22.473938

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