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bioRxiv · 10.1101/2021.12.20.473542

Structural flexibility of the SARS-CoV-2 genome relevant to variation, replication, pathogenicity, and immune evasion.

Patarca, R.·Haseltine, W. A.
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Abstract

The SARS-CoV-2 pandemic continues to be driven by viral variants. Most research has focused on structural proteins and on site-specific mutations. Here, we describe recombination events involving genomic terminal sequences in SARS-CoV-2 and related viruses leading to structural rearrangements in terminal and coding regions and discuss their potential contributions to viral variation, replication, pathogenicity, and immune evasion.

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Patarca, R., Haseltine, W. A.. 2021-12-21. Structural flexibility of the SARS-CoV-2 genome relevant to variation, replication, pathogenicity, and immune evasion.. https://doi.org/10.1101/2021.12.20.473542

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