Differing Associations between Optic Nerve Head Strains and Visual Field Loss in Normal- and High-Tension Glaucoma Subjects

Chuangsuwanich, T.; Tun, T. A.; Wang, X.; Chin, Z. Y.; Panda, S. K.; Buist, M.; Strouthidis, N.; Perera, S.; Nongpiur, M.; Aung, T.; Girard, M. J. A.

doi:10.1101/2021.12.15.472712

bioRxiv · 10.1101/2021.12.15.472712

Differing Associations between Optic Nerve Head Strains and Visual Field Loss in Normal- and High-Tension Glaucoma Subjects

Chuangsuwanich, T.·Tun, T. A.·Wang, X.·Chin, Z. Y.·Panda, S. K.·Buist, M.·Strouthidis, N.·Perera, S.·Nongpiur, M.·Aung, T.·Girard, M. J. A.

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Abstract

PurposeTo study the associations between optic nerve head (ONH) strains under intraocular pressure (IOP) elevation with retinal sensitivity in glaucoma subjects. DesignClinic based cross-sectional study. Participants229 subjects with primary open angle glaucoma (subdivided into 115 high tension glaucoma (HTG) subjects and 114 normal tension glaucoma (NTG) subjects). MethodsFor one eye of each subject, we imaged the ONH using spectral-domain optical coherence tomography (OCT) under the following conditions: (1) primary gaze and (2) primary gaze with acute IOP elevation (to approximately 33 mmHg) achieved through ophthalmodynamometry. A 3-dimensional (3D) strain-mapping algorithm was applied to quantify IOP-induced ONH tissue strain (i.e. deformation) in each ONH. Strains in the pre-lamina tissue (PLT)and the retina, the choroid, the sclera and the lamina cribrosa (LC) were associated (using linear regression) with measures of retinal sensitivity from the 24-2 Humphrey visual field test (Carl Zeiss Meditec, Dublin, CA, USA). This was done globally, then locally according to the regionalization scheme of Garway-Heath et al. Main Outcome MeasuresAssociations between ONH strains and values of retinal sensitivity from visual field testing. ResultsFor HTG subjects, we found that (1) there were significant negative linear associations between ONH strains and retinal sensitivity (p<0.001) (on average, a 1% increase in ONH strains corresponded to a decrease in retinal sensitivity of 1.1 dB), (2) high strain regions co-localized with anatomically-mapped regions of high visual field loss, (3) the strongest negative associations were observed in the superior region and in the PLT. In contrast, for NTG subjects, no significant associations between strains and retinal sensitivity were observed except in the supero-temporal region of the LC. ConclusionWe found significant negative associations between IOP-induced ONH strains and retinal sensitivity in a relatively large glaucoma cohort. Specifically, HTG subjects who experienced higher ONH strains were more likely to exhibit lower retinal sensitivities. Interestingly, this trend was in general less pronounced in NTG subjects, which could suggest a distinct pathophysiology between the two glaucoma subtypes.

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Chuangsuwanich, T., Tun, T. A., Wang, X., Chin, Z. Y., Panda, S. K., Buist, M., Strouthidis, N., Perera, S., Nongpiur, M., Aung, T., Girard, M. J. A.. 2021-12-16. Differing Associations between Optic Nerve Head Strains and Visual Field Loss in Normal- and High-Tension Glaucoma Subjects. https://doi.org/10.1101/2021.12.15.472712

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