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bioRxiv · 10.1101/2021.12.06.470936

TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation

Fischer, M.·Riege, K.·Schwarz, R.·DeCaprio, J. A.·Hoffmann, S.
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Abstract

In recent years, our web-atlas at www.TargetGeneReg.org has enabled many researchers to uncover new biological insights and to identify novel regulatory mechanisms that affect p53 and the cell cycle - signaling pathways that are frequently dysregulated in diseases like cancer. Here, we provide a substantial upgrade of the database that comprises an extension to include non-coding genes and the transcription factors {Delta}Np63 and RFX7. TargetGeneReg 2.0 combines gene expression profiling and transcription factor DNA binding data to determine, for each gene, the response to p53, {Delta}Np63, and cell cycle signaling. It can be used to dissect common, cell type, and treatment-specific effects, identify the most promising candidates, and validate findings. We demonstrate the increased power and more intuitive layout of the resource using realistic examples.

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Fischer, M., Riege, K., Schwarz, R., DeCaprio, J. A., Hoffmann, S.. 2021-12-07. TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation. https://doi.org/10.1101/2021.12.06.470936

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