Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Romitti, M.; de Faria da Fonseca, B.; Doumont, G.; Gillotay, P.; Tourneur, A.; Eski, S. E.; Van Simaeys, G.; Chomette, L.; Lasolle, h.; Monestier, O.; Figini Kasprzyk, D.; Detours, V.; Singh, S. P.; Goldman, S.; Refetoff, S. P.; Costagliola, S.

doi:10.1101/2021.12.01.470729

bioRxiv · 10.1101/2021.12.01.470729

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Romitti, M.·de Faria da Fonseca, B.·Doumont, G.·Gillotay, P.·Tourneur, A.·Eski, S. E.·Van Simaeys, G.·Chomette, L.·Lasolle, h.·Monestier, O.·Figini Kasprzyk, D.·Detours, V.·Singh, S. P.·Goldman, S.·Refetoff, S. P.·Costagliola, S.

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Abstract

The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, functional human thyroid organoids could pave the way to explore new therapeutic approaches. Here we report the first transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone to athyreotic mice as a proof of concept for future therapeutic development.

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Romitti, M., de Faria da Fonseca, B., Doumont, G., Gillotay, P., Tourneur, A., Eski, S. E., Van Simaeys, G., Chomette, L., Lasolle, h., Monestier, O., Figini Kasprzyk, D., Detours, V., Singh, S. P., Goldman, S., Refetoff, S. P., Costagliola, S.. 2021-12-01. Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism. https://doi.org/10.1101/2021.12.01.470729

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