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bioRxiv · 10.1101/2021.11.23.469665

A family of cell wall transglutaminases is essential for appressorium development and pathogenicity in Phytophthora infestans

Abstract

Transglutaminases (TGases) are enzymes highly conserved among prokaryotic and eukaryotic organisms, where their role is to catalyse protein cross-linking. One of the putative TGases of Phytophthora infestans has previously been shown to be localised to the cell wall. Based on sequence similarity we were able to identify six more genes annotated as putative TGases and show that these seven genes group together in phylogenetic analysis. All of the seven proteins are predicted to contain transmembrane helices and both a TGase domain and a MANSC domain, the latter of which was previously shown to play a role in protein stability. Chemical inhibition of transglutaminase activity and silencing of the entire family of the putative cell wall TGases are both lethal to P. infestans indicating the importance of these proteins in cell wall formation and stability. The intermediate phenotype obtained with lower drug concentrations and less efficient silencing displays a number of deformations to germ tubes and appressoria. Both chemically treated and silenced lines show lower pathogenicity than the wild type in leaf infection assays. Finally, we show that appressoria of P. infestans possess the ability to build up turgor pressure and that this ability is decreased by chemical inhibition of TGases.

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BibTeXRIS

Brus-Szkalej, M., Andersen, C. B., Vetukuri, R. R., Grenville-Briggs Didymus, L. J.. 2021-11-23. A family of cell wall transglutaminases is essential for appressorium development and pathogenicity in Phytophthora infestans. https://doi.org/10.1101/2021.11.23.469665

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