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bioRxiv · 10.1101/2021.11.20.469406

A structured scaffold underlies activity in the hippocampus

Abstract

Place cells are believed to organize memory across space and time, inspiring the idea of the cognitive map. Yet unlike the structured activity in the associated grid and head-direction cells, they remain an enigma: their responses have been difficult to predict and are complex enough to be statistically well-described by a random process. Here we report one step toward the ultimate goal of understanding place cells well enough to predict their fields. Within a theoretical framework in which place fields are derived as a conjunction of external cues with internal grid cell inputs, we predict that even apparently random place cell responses should reflect the structure of their grid inputs and that this structure can be unmasked if probed in sufficiently large neural populations and large environments. To test the theory, we design experiments in long, locally featureless spaces to demonstrate that structured scaffolds undergird place cell responses. Our findings, together with other theoretical and experimental results, suggest that place cells build memories of external inputs by attaching them to a largely prespecified grid scaffold.

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Mulders, D., Yim, M. Y., Lee, J. S., Lee, A. K., Taillefumier, T., Fiete, I.. 2021-11-22. A structured scaffold underlies activity in the hippocampus. https://doi.org/10.1101/2021.11.20.469406

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