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bioRxiv · 10.1101/2021.11.16.468438

A recurrent circuit links antagonistic cerebellar modules during associative motor learning

Abstract

The neural architecture of the cerebellum is thought to be specialized for performing supervised learning: specific error-related climbing fiber inputs are used to teach sensorimotor associations to small ensembles of Purkinje cells located in functionally distinct modules that operate independently of each other in a purely feedforward manner. Here, we test whether the basic operation of the cerebellum complies with this basic architecture in mice that learned a simple sensorimotor association during eyeblink conditioning. By recording Purkinje cells in different modules and testing whether their responses rely on recurrent circuits, our results reveal three operational principles about the functional organization of the cerebellum that stand in stark contrast to the conventional view: (1) Antagonistic organization, (2) Recurrent network dynamics, and (3) Intermodular communication. We propose that the neural architecture of the cerebellum implements these three operational principles to achieve optimal performance and solve a number of problems in motor control.

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BibTeXRIS

Ohmae, S., Ohmae, K., Heiney, S. A., Subramanian, D., Medina, J. F.. 2021-11-17. A recurrent circuit links antagonistic cerebellar modules during associative motor learning. https://doi.org/10.1101/2021.11.16.468438

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