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bioRxiv · 10.1101/2021.11.08.467784

Gattaca: Base pair resolution mutation tracking for somatic evolution studies using agent-based models

Schenck, R. O.·Brosula, G.·West, J.·Leedham, S.·Shibata, D.·Anderson, A. R.
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Abstract

Gattaca provides the first base-pair resolution artificial genomes for tracking somatic mutations within agent based modeling. Through the incorporation of human reference genomes, mutational context, sequence coverage/error information Gattaca is able to realistically provide comparable sequence data for in-silico comparative evolution studies with human somatic evolution studies. This user-friendly method, incorporated into each in-silico cell, allows us to fully capture somatic mutation spectra and evolution.

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Schenck, R. O., Brosula, G., West, J., Leedham, S., Shibata, D., Anderson, A. R.. 2021-11-13. Gattaca: Base pair resolution mutation tracking for somatic evolution studies using agent-based models. https://doi.org/10.1101/2021.11.08.467784

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