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bioRxiv · 10.1101/2021.10.27.466092

MPDB: a unified multi-domain protein structure database integrating structural analogue detection

Peng, C.·Zhou, X.·Xia, Y.·Zhang, Y.·Zhang, G.
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Abstract

With the development of protein structure prediction methods and biological experimental determination techniques, the structure of single-domain proteins can be relatively easier to be modeled or experimentally solved. However, more than 80% of eukaryotic proteins and 67% of prokaryotic proteins contain multiple domains. Constructing a unified multi-domain protein structure database will promote the research of multi-domain proteins, especially in the modeling of multi-domain protein structures. In this work, we develop a unified multi-domain protein structure database (MPDB). Based on MPDB, we also develop a server with two functional modules: (1) the culling module, which filters the whole MPDB according to input criteria; (2) the detection module, which identifies structural analogues of the full-chain according to the structural similarity between input domain models and the protein in MPDB. The module can discover the potential analogue structures, which will contribute to high-quality multi-domain protein structure modeling.

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Peng, C., Zhou, X., Xia, Y., Zhang, Y., Zhang, G.. 2021-10-28. MPDB: a unified multi-domain protein structure database integrating structural analogue detection. https://doi.org/10.1101/2021.10.27.466092

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