A data-informed mean-field approach to mapping of cortical parameter landscapes

Abstract

Constraining the many biological parameters that govern cortical dynamics is computa-tionally and conceptually difficult because of the curse of dimensionality. This paper addresses these challenges by proposing (1) a novel data-informed mean-field (MF) approach to efficiently map the parameter space of network models; and (2) an organizing principle for studying parameter space that enables the extraction biologically meaningful relations from this high-dimensional data. We illustrate these ideas using a large-scale network model of the Macaque primary visual cortex. Of the 10-20 model parameters, we identify 7 that are especially poorly constrained, and use the MF algorithm in (1) to discover the firing rate contours in this 7D parameter cube. Defining a "biologically plausible" region to consist of parameters that exhibit spontaneous Excitatory and Inhibitory firing rates compatible with experimental values, we find that this region is a slightly thickened codimension-1 submanifold. An implication of this finding is that while plausible regimes depend sensitively on parameters, they are also robust and flexible provided one compensates appropriately when parameters are varied. Our organizing principle for conceptualizing parameter dependence is to focus on certain 2D parameter planes that govern lateral inhibition: Intersecting these planes with the biologically plausible region leads to very simple geometric structures which, when suitably scaled, have a universal character independent of where the intersections are taken. In addition to elucidating the geometry of the plausible region, this invariance suggests useful approximate scaling relations. Our study offers, for the first time, a complete characterization of the set of all biologically plausible parameters for a detailed cortical model, which has been out of reach due to the high dimensionality of parameter space. Author SummaryCortical circuits are characterized by a high degree of structural and dynamical complexity, and this biological reality is reflected in the large number of parameters in even semi-realistic cortical models. A fundamental task of computational neuroscience is to understand how these parameters govern network dynamics. While some neuronal parameters can be measured in vivo, many remain poorly constrained due to limitations of available experimental techniques. Computational models can address this problem by relating difficult-to-measure parameters to observable quantities, but to do so one must overcome two challenges: (1) the computational expense of mapping a high dimensional parameter space, and (2) extracting biological insights from such a map. This study aims to address these challenges in the following ways: First, we propose a parsimonious data-informed algorithm that efficiently predicts spontaneous cortical activity, thereby speeding up the mapping of parameter landscapes. Second, we show that lateral inhibition provides a basis for conceptualizing cortical parameter space, enabling us to begin to make sense of its geometric structure and attendant scaling relations. We illustrate our approach on a biologically realistic model of the monkey primary visual cortex.