The protein folding rate and the geometry and topology of the native state

Wang, J. J.; Panagiotou, E.

doi:10.1101/2021.10.06.463425

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bioRxiv · 10.1101/2021.10.06.463425

The protein folding rate and the geometry and topology of the native state

Wang, J. J.·Panagiotou, E.

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Abstract

Proteins fold in 3-dimensional conformations which are important for their function. Characterizing the global conformation of proteins rigorously and separating secondary structure effects from topological effects is a challenge. New developments in Applied Knot Theory allow to characterize the topological characteristics of proteins (knotted or not). By analyzing a small set of two-state and multi-state proteins with no knots or slipknots, our results show that 95.4% of the analyzed proteins have non-trivial topological characteristics, as reflected by the second Vassiliev measure, and that the logarithm of the experimental protein folding rate depends on both the local geometry and the topology of the proteins native state.

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Wang, J. J., Panagiotou, E.. 2021-10-07. The protein folding rate and the geometry and topology of the native state. https://doi.org/10.1101/2021.10.06.463425

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