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bioRxiv · 10.1101/2021.09.26.461880

How to model DNA replication in stochastic models of synthetic genetic circuits (and why)

Clamons, S.·Murray, R. M.
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Abstract

Biocircuit modeling sometimes requires explicit tracking of a self-replicating DNA species. The most obvious, straightforward way to model a replicating DNA is structurally unstable and leads to pathological model behavior. We describe a simple, stable replication mechanism with good model behavior and show how to derive it from a mechanistic model of ColE1 replication.

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Clamons, S., Murray, R. M.. 2021-09-27. How to model DNA replication in stochastic models of synthetic genetic circuits (and why). https://doi.org/10.1101/2021.09.26.461880

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