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bioRxiv · 10.1101/2021.09.13.460087

Structural Disconnection of the Posterior Medial Frontal Cortex Reduces Speech Error Monitoring

Abstract

Optimal performance in any task relies on the ability to detect and repair errors. The anterior cingulate cortex and the broader posterior medial frontal cortex (pMFC) are active during error processing. However, it is unclear whether damage to the pMFC impairs error monitoring. We hypothesized that successful error monitoring critically relies on connections between the pMFC and broader cortical networks involved in executive functions and the task being monitored. We tested this hypothesis in the context of speech error monitoring in people with post-stroke aphasia. Diffusion weighted images were collected in 51 adults with chronic left-hemisphere stroke and 37 age-matched control participants. Whole-brain connectomes were derived using constrained spherical deconvolution and anatomically-constrained probabilistic tractography. Support vector regressions identified white matter connections in which lost integrity in stroke survivors related to reduced error detection during confrontation naming. Lesioned connections to the bilateral pMFC were related to reduce error monitoring, including many connections to regions associated with speech production and executive function. We conclude that connections to the pMFC support error monitoring. Error monitoring in speech production is supported by the structural connectivity between the pMFC and regions involved in speech production and executive function. Interactions between pMFC and other taskrelevant processors may similarly be critical for error monitoring in other task contexts.

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BibTeXRIS

McCall, J., Dickens, J. V., Mandal, A., DeMarco, A. T., Fama, M., Lacey, E., Kelkar, A., Medaglia, J., Turkeltaub, P.. 2021-09-15. Structural Disconnection of the Posterior Medial Frontal Cortex Reduces Speech Error Monitoring. https://doi.org/10.1101/2021.09.13.460087

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