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bioRxiv · 10.1101/2021.09.08.458120

Spinal reconsolidation engages non-ionotropic NMDA receptor signaling to reverse pain hypersensitivity

D'Souza, A. J.·Rodriguez-Hernandez, D.·Zhang, H.·He, D.·Zain, M.·Fung, S.·Bennett, L. A.·Bonin, R. P.
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Abstract

Reconsolidation enables the activity-dependent modification of memory traces and has been used to reverse addiction, fear memory, and pain hypersensitivity in animal models. We demonstrate that non-ionotropic NMDA receptor signalling in the spinal dorsal horn is sufficient to reverse pain hypersensitivity and necessary for pain modulation by spinal reconsolidation. These findings reveal a key process by which reconsolidation disrupts memory traces that may be exploited in the treatment of pain and other disorders.

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D'Souza, A. J., Rodriguez-Hernandez, D., Zhang, H., He, D., Zain, M., Fung, S., Bennett, L. A., Bonin, R. P.. 2021-09-09. Spinal reconsolidation engages non-ionotropic NMDA receptor signaling to reverse pain hypersensitivity. https://doi.org/10.1101/2021.09.08.458120

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