AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

Potjewyd, F. M.; Annor-Gyamfi, J. K.; Aube, J.; Chu, S.; Conlon, I. L.; Frankowski, K. J.; Guduru, S. K. R.; Hardy, B. P.; Hopkins, M. D.; Kinoshita, C.; Kireev, D. B.; Mason, E. R.; Moerk, C. T.; Nwogbo, F.; Pearce, K. H.; Richardson, T.; Rogers, D. A.; Soni, D. M.; Stashko, M.; Wang, X.; Wells, C.; Willson, T. M.; Frye, S. V.; Young, J. E.; Axtman, A. D.

doi:10.1101/2021.07.22.453404

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bioRxiv · 10.1101/2021.07.22.453404

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

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Abstract

IntroductionThe portfolio of novel targets to treat Alzheimers disease (AD) has been enriched by the AMP-AD program. MethodsA cheminformatics-driven effort enabled identification of existing small molecule modulators for many protein targets nominated by AMP-AD and suitable positive control compounds to be included in the set. ResultsWe have built an annotated set of 171 small molecule modulators, including mostly inhibitors, targeting 98 unique proteins that have been nominated by AMP-AD consortium members as novel targets for AD treatment. These small molecules vary in their quality and should be considered chemical tools that can be used in efforts to validate therapeutic hypotheses, but which would require further optimization. A physical copy of the AD Informer Set can be ordered via the AD Knowledge Portal. DiscussionSmall molecule tools that enable target validation are important tools for the translation of novel hypotheses into viable therapeutic strategies for AD.

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Potjewyd, F. M., Annor-Gyamfi, J. K., Aube, J., Chu, S., Conlon, I. L., Frankowski, K. J., Guduru, S. K. R., Hardy, B. P., Hopkins, M. D., Kinoshita, C., Kireev, D. B., Mason, E. R., Moerk, C. T., Nwogbo, F., Pearce, K. H., Richardson, T., Rogers, D. A., Soni, D. M., Stashko, M., Wang, X., Wells, C., Willson, T. M., Frye, S. V., Young, J. E., Axtman, A. D.. 2021-07-23. AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery. https://doi.org/10.1101/2021.07.22.453404

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