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bioRxiv · 10.1101/2021.07.18.452866

A New Proposal of an Index for Regional Cerebral Perfusion Pressure - A Theoretical Approach with Fluid Dynamics

Kameyama, M.·Momose, T.
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Abstract

Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [15O] H2O/ CO2 and CO positron emission tomography (PET) examination has been used empirically as an index for cerebral perfusion pressure (CPP). However, this equation lacks a theoretical basis and furthermore, has not been confirmed to be proportionate to CPP, as direct measurement of local CPP is not practical. We have developed a new index for CPP using the Poiseuille equation based on a simple model. Our model suggests that CBF/CBV2 is proportionate to CPP and that it is mathematically a more accurate index than CBF/CBV.

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Kameyama, M., Momose, T.. 2021-07-20. A New Proposal of an Index for Regional Cerebral Perfusion Pressure - A Theoretical Approach with Fluid Dynamics. https://doi.org/10.1101/2021.07.18.452866

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