Dissociable Multi-scale Patterns of Development in Personalized Brain Networks

Pines, A. R.; Larsen, B.; Cui, Z.; Sydnor, V. J.; Bertolero, M. A.; Adebimpe, A.; Alexander-Bloch, A. F.; Davatzikos, C.; Fair, D. A.; Gur, R. C.; Gur, R. E.; Li, H.; Milham, M. P.; Moore, T. M.; Murtha, K.; Parkes, L.; Thompson-Schill, S. L.; Shanmugan, S.; Shinohara, R. T.; Weinstein, S. M.; Bassett, D. S.; Fan, Y.; Satterthwaite, T. D.

doi:10.1101/2021.07.07.451458

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bioRxiv · 10.1101/2021.07.07.451458

Dissociable Multi-scale Patterns of Development in Personalized Brain Networks

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Abstract

The brain is organized into networks at multiple resolutions, or scales, yet studies of functional network development typically focus on a single scale. Here, we derived personalized functional networks across 29 scales in a large sample of youths (n=693, ages 8-23 years) to identify multi-scale patterns of network re-organization related to neurocognitive development. We found that developmental shifts in inter-network coupling systematically adhered to and strengthened a functional hierarchy of cortical organization. Furthermore, we observed that scale-dependent effects were present in lower-order, unimodal networks, but not higher-order, transmodal networks. Finally, we found that network maturation had clear behavioral relevance: the development of coupling in unimodal and transmodal networks dissociably mediated the emergence of executive function. These results delineate maturation of multi-scale brain networks, which varies according to a functional hierarchy and impacts cognitive development.

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Pines, A. R., Larsen, B., Cui, Z., Sydnor, V. J., Bertolero, M. A., Adebimpe, A., Alexander-Bloch, A. F., Davatzikos, C., Fair, D. A., Gur, R. C., Gur, R. E., Li, H., Milham, M. P., Moore, T. M., Murtha, K., Parkes, L., Thompson-Schill, S. L., Shanmugan, S., Shinohara, R. T., Weinstein, S. M., Bassett, D. S., Fan, Y., Satterthwaite, T. D.. 2021-07-09. Dissociable Multi-scale Patterns of Development in Personalized Brain Networks. https://doi.org/10.1101/2021.07.07.451458

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