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bioRxiv · 10.1101/2021.07.05.451093

Identification of the Novel Pyroptosis-Related Gene Signature in Patients with Esophageal Adenocarcinoma

Zeng, R.·Huang, S.·Zhuo, Z.·Wu, H.·Sha, W.·Chen, H.
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Abstract

Esophageal adenocarcinoma (EAC) is a highly malignant type of digestive tract cancers with a poor prognosis despite therapeutic advances. Pyroptosis is an inflammatory form of programmed cell death, whereas the role of pyroptosis in EAC remains largely unknown. Herein, we identified a pyroptosis-related five-gene signature that was significantly correlated with the survival of EAC patients in The Cancer Genome Atlas (TCGA) cohort and an independent validation dataset. In addition, a nomogram based on the five-gene signature was constructed with novel prognostic values. Moreover, the genes in the pyroptosis-related signature, CASP1, GSDMB, IL1B, PYCARD, and ZBP1, might be involved in immune response and regulation of the tumor microenvironment. Our findings indicate that the five-gene signature provides insights into the involvement of pyroptosis in EAC progression, and is promising in the risk assessment as well as prognosis for EAC patients in clinical practice.

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Zeng, R., Huang, S., Zhuo, Z., Wu, H., Sha, W., Chen, H.. 2021-07-05. Identification of the Novel Pyroptosis-Related Gene Signature in Patients with Esophageal Adenocarcinoma. https://doi.org/10.1101/2021.07.05.451093

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