Hippocampal neurons code individual memory episodes in humans

Kolibius, L. D.; Roux, F.; Parish, G. M.; ter Wal, M. J.; Van Der Plas, M.; Chelvarajah, R.; Sawlani, V.; Rollings, D.; Lang, J.; Gollwitzer, S.; Hopfengaertner, R.; Kreiselmeyer, G.; Hamer, H.; Staresina, B. P.; Wimber, M.; Bowman, H.; Hanslmayr, S.

doi:10.1101/2021.06.28.450149

bioRxiv · 10.1101/2021.06.28.450149

Hippocampal neurons code individual memory episodes in humans

Kolibius, L. D.·Roux, F.·Parish, G. M.·ter Wal, M. J.·Van Der Plas, M.·Chelvarajah, R.·Sawlani, V.·Rollings, D.·Lang, J.·Gollwitzer, S.·Hopfengaertner, R.·Kreiselmeyer, G.·Hamer, H.·Staresina, B. P.·Wimber, M.·Bowman, H.·Hanslmayr, S.

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Abstract

The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. Some argue that each hippocampal neuron codes for an invariant element within an episode. Instead, others have proposed that hippocampal neurons bind together all elements present in a discrete episodic memory. Here, we provide evidence for the latter. We show that individual neurons, which we term Episode Specific Neurons (ESNs), code discrete episodic memories using either a rate code or a temporal firing code. We find evidence for these neurons exclusively in the hippocampus. Importantly, these ESNs do not reflect the coding of a particular element in the episode (i.e., concept or time). Instead, they code for the conjunction of the different elements that make up the episode. One-Sentence SummaryIndividual neurons in the hippocampus code for discrete episodic memories.

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Kolibius, L. D., Roux, F., Parish, G. M., ter Wal, M. J., Van Der Plas, M., Chelvarajah, R., Sawlani, V., Rollings, D., Lang, J., Gollwitzer, S., Hopfengaertner, R., Kreiselmeyer, G., Hamer, H., Staresina, B. P., Wimber, M., Bowman, H., Hanslmayr, S.. 2021-06-29. Hippocampal neurons code individual memory episodes in humans. https://doi.org/10.1101/2021.06.28.450149

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