Ipsilesional motor cortex activation with high-force unimanual handgrip contractions of the less-affected limb in participants with stroke

Andrushko, J. W.; Gould, L.; Renshaw, D. W.; Forrester, S.; Kelly, M. E.; Linassi, G.; Mickleborough, M.; Oates, A.; Hunter, G.; Borowsky, R.; Farthing, J. P.

doi:10.1101/2021.06.25.449456

bioRxiv · 10.1101/2021.06.25.449456

Ipsilesional motor cortex activation with high-force unimanual handgrip contractions of the less-affected limb in participants with stroke

Andrushko, J. W.·Gould, L.·Renshaw, D. W.·Forrester, S.·Kelly, M. E.·Linassi, G.·Mickleborough, M.·Oates, A.·Hunter, G.·Borowsky, R.·Farthing, J. P.

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Abstract

Stroke is a leading cause of severe disability that often presents with unilateral motor impairment. Conventional rehabilitation approaches focus on motor practice of the affected limb and aim to suppress brain activity in the contralesional hemisphere to facilitate ipsilesional hemispheric neuroplasticity subserving motor recovery. Previous research has also demonstrated that exercise of the less-affected limb can promote motor recovery of the affected limb through the interlimb transfer of the trained motor task, termed cross-education. One of the leading theories for cross-education proposes that the interlimb transfer manifests from ipsilateral cortical activity during unimanual motor tasks, and that this ipsilateral cortical activity results in motor related neuroplasticity giving rise to contralateral improvements in motor performance. Conversely, exercise of the less-affected limb promotes contralesional brain activity which is typically viewed as contraindicated in stroke recovery due to the interhemispheric inhibitory influence onto the ipsilesional hemisphere. High-force unimanual handgrip contractions are known to increase ipsilateral brain activation in control participants, but it remains to be determined if this would be observed in participants with stroke. Therefore, this study aimed to determine how parametric increases in handgrip force during repeated contractions with the less-affected limb impacts brain activity bilaterally in participants with stroke and in a cohort of neurologically intact controls. In this study, higher force contractions were found to increase brain activation in the ipsilesional/ipsilateral hemisphere in both groups (p = .002), but no between group differences were observed. These data suggest that high-force exercise with the less-affected limb may promote ipsilesional cortical plasticity to promote motor recovery of the affected-limb in participants with stroke.

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Andrushko, J. W., Gould, L., Renshaw, D. W., Forrester, S., Kelly, M. E., Linassi, G., Mickleborough, M., Oates, A., Hunter, G., Borowsky, R., Farthing, J. P.. 2021-06-27. Ipsilesional motor cortex activation with high-force unimanual handgrip contractions of the less-affected limb in participants with stroke. https://doi.org/10.1101/2021.06.25.449456

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