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bioRxiv · 10.1101/2021.06.21.449230

Visualizing sequential compound fusion and kiss-and-run in live excitable cells

Ge, L.·Shin, W.·Wu, L.-G.
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Abstract

Vesicle fusion is assumed to occur at flat membrane of excitable cells. In live neuroendocrine cells, we visualized vesicle fusion at {Omega}-shape membrane generated by preceding fusion, termed sequential compound fusion, which may be followed by fusion pore closure, termed compound kiss-and-run. These novel fusion modes contribute to vesicle docking, multi-vesicular release, asynchronous release, and endocytosis. We suggest modifying current models of exo-endocytosis to include these new fusion modes.

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Ge, L., Shin, W., Wu, L.-G.. 2021-06-22. Visualizing sequential compound fusion and kiss-and-run in live excitable cells. https://doi.org/10.1101/2021.06.21.449230

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