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bioRxiv · 10.1101/2021.06.21.449182

Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2

Kageyama, T.·Tanaka, S.·Etori, K.·Hattori, K.·Miyachi, K.·Kasuya, T.·Iwamoto, T.·Ikeda, K.·Igari, H.·Yokote, K.·Nakajima, H.
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Abstract

We analyzed peripheral blood mononuclear cells (PBMCs) of each 20 individuals with a high anti-SARS-CoV-2 antibody titer and a low antibody titer out of 1,774 healthcare workers who received BNT162b2 mRNA vaccine. A higher antibody titer was associated with the frequencies of naive and transitional B cells before vaccination. In addition, fold changes in the frequency of activated CD8+ T cells upon vaccination were correlated with the antibody titers.

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Kageyama, T., Tanaka, S., Etori, K., Hattori, K., Miyachi, K., Kasuya, T., Iwamoto, T., Ikeda, K., Igari, H., Yokote, K., Nakajima, H.. 2021-06-21. Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2. https://doi.org/10.1101/2021.06.21.449182

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