SARS coronavirus vaccines protect against different coronaviruses

Dangi, T.; Palacio, N.; Sanchez, S.; Class, J.; Visvabharathy, L.; Ciucci, T.; Koralnik, I.; Richner, J.; Penaloza-MacMaster, P.

doi:10.1101/2021.06.01.446491

bioRxiv · 10.1101/2021.06.01.446491

SARS coronavirus vaccines protect against different coronaviruses

Dangi, T.·Palacio, N.·Sanchez, S.·Class, J.·Visvabharathy, L.·Ciucci, T.·Koralnik, I.·Richner, J.·Penaloza-MacMaster, P.

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Abstract

Although SARS-CoV-2 vaccines have shown efficacy against SARS-CoV-2, it is unclear if they can also protect against other coronaviruses that may infect humans in the future. Here, we show that SARS-CoV-2 vaccination in humans elicits cross-reactive antibodies against other coronaviruses. Our studies in mice demonstrate that SARS-CoV-2 vaccination protects against a common cold coronavirus, and that SARS-CoV-1 vaccination protects against SARS-CoV-2. Similarly, infection with a common cold coronavirus also conferred enhanced protection from subsequent infections with other coronaviruses. Mechanistically, both T cells and antibodies mediated cross-protection. This is the first direct demonstration that coronavirus-specific immunity can confer heterologous protection in vivo, providing a rationale for universal coronavirus vaccines. HighlightsO_LISARS-CoV-2 vaccination elicits cross-reactive antibody against other coronaviruses in humans. C_LIO_LICOVID-19 patients generate cross-reactive antibody against other coronaviruses. C_LIO_LIA SARS-CoV-1 vaccine protects against SARS-CoV-2. C_LIO_LIPrior coronavirus infections improve immune protection following heterologous coronavirus challenges. C_LI

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Dangi, T., Palacio, N., Sanchez, S., Class, J., Visvabharathy, L., Ciucci, T., Koralnik, I., Richner, J., Penaloza-MacMaster, P.. 2021-06-01. SARS coronavirus vaccines protect against different coronaviruses. https://doi.org/10.1101/2021.06.01.446491

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