Automated detection of artefacts in neonatal EEG with residual neural networks

Abstract

Background and ObjectiveTo develop a computational algorithm that detects and identifies different artefact types in neonatal electroencephalography (EEG) signals. MethodsAs part of a larger algorithm, we trained a Residual Deep Neural Network on expert human annotations of EEG recordings from 79 term infants recorded in a neonatal intensive care unit (112 h of 18-channel recording). The network was trained using 10 fold cross validation in Matlab. Artefact types included: device interference, EMG, movement, electrode pop, and non-cortical biological rhythms. Performance was assessed by prediction statistics and further validated on a separate independent dataset of 13 term infants (143 h of 3-channel recording). EEG pre-processing steps, and other post-processing steps such as averaging probability over a temporal window, were also included in the algorithm. ResultsThe Residual Deep Neural Network showed high accuracy (95%) when distinguishing periods of clean, artefact-free EEG from any kind of artefact, with a median accuracy for individual patient of 91% (IQR: 81%-96%). The accuracy in identifying the five different types of artefacts ranged from 57%-92%, with electrode pop being the hardest to detect and EMG being the easiest. This reflected the proportion of artefact available in the training dataset. Misclassification as clean was low for each artefact type, ranging from 1%-11%. The detection accuracy was lower on the validation set (87%). We used the algorithm to show that EEG channels located near the vertex were the least susceptible to artefact. ConclusionArtefacts can be accurately and reliably identified in the neonatal EEG using a deep learning algorithm. Artefact detection algorithms can provide continuous bedside quality assessment and support EEG review by clinicians or analysis algorithms. HighlightsO_LIWe applied a Residual Deep Neural Network as part of an artefact detection algorithm in neonatal electroencephalograms. C_LIO_LIThe algorithm shows high accuracy in identifying artefactual data in general and for specific artefact types. C_LIO_LIEEG channels near the top of the head are less prone to artefact. C_LI