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bioRxiv · 10.1101/2021.05.21.445119

Probenecid Inhibits SARS-CoV-2 Replication In Vivo and In Vitro

Murray, J.·Hogan, R. J.·Martin, D. E.·Blahunka, K.·Sancillo, F.·Balyan, R.·Lovern, M.·Still, R.·Tripp, R. A.
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Abstract

Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate that plasma concentrations up to 50-fold higher than the protein binding adjusted IC90 value are achievable for 24h following a single oral dose. These data support the potential clinical utility of probenecid to control SARS-CoV-2 infection in humans.

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Murray, J., Hogan, R. J., Martin, D. E., Blahunka, K., Sancillo, F., Balyan, R., Lovern, M., Still, R., Tripp, R. A.. 2021-05-21. Probenecid Inhibits SARS-CoV-2 Replication In Vivo and In Vitro. https://doi.org/10.1101/2021.05.21.445119

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