Neuro-musculoskeletal Upper Limb in-silico asvirtual patient

Kapardi, M.; Pithapuram, M.; Iyengar, R. S.; Yashaswini, M. R.; Singh, A. K.; Sripada, S.; Raghavan, M.

doi:10.1101/2021.05.16.444298

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bioRxiv · 10.1101/2021.05.16.444298

Neuro-musculoskeletal Upper Limb in-silico asvirtual patient

Kapardi, M.·Pithapuram, M.·Iyengar, R. S.·Yashaswini, M. R.·Singh, A. K.·Sripada, S.·Raghavan, M.

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Abstract

Virtual patients and physiologies allow experimentation, design, and early-stage clinical trials in-silico. Virtual patient technology for human movement systems that encompasses musculoskeleton and its neural control are few and far in between. In this work, we present one such neuro-musculoskeletal upper limb in-silico model. This upper limb is both modular in architecture and generates movement as an emergent phenomenon out of a multiscale co-simulation of spinal cord neural control and musculoskeletal dynamics. It is developed on the NEUROiD movement simulation platform that enables a co-simulation of popular neural simulator NEURON and the musculoskeletal simulator OpenSim. In this work, we describe the design and development of the upper limb in a modular fashion, while reusing existing models and modules. We further characterize and demonstrate the use of this model in generating a range of commonly observed movements by means of a spatio temporal stimulation pattern delivered to the cervical spinal cord. We believe this work enables a first and small step towards an in-silico paradigms for understanding upper limb movement, disease pathology, medication, and rehabilitation.

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Kapardi, M., Pithapuram, M., Iyengar, R. S., Yashaswini, M. R., Singh, A. K., Sripada, S., Raghavan, M.. 2021-05-17. Neuro-musculoskeletal Upper Limb in-silico asvirtual patient. https://doi.org/10.1101/2021.05.16.444298

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