Iota-carrageenan prevents the replication of SARS-CoV-2 on an in vitro respiratory epithelium model

Varese, A.; Ceballos, A.; Palacios, C. A.; Figueroa, J. M.; Dugour, A. V.

doi:10.1101/2021.04.27.441512

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bioRxiv · 10.1101/2021.04.27.441512

Iota-carrageenan prevents the replication of SARS-CoV-2 on an in vitro respiratory epithelium model

Varese, A.·Ceballos, A.·Palacios, C. A.·Figueroa, J. M.·Dugour, A. V.

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Abstract

There are, except for remdesivir, no approved antivirals for the treatment or prevention of SARS-CoV-2 infections. Iota-carrageenan formulated into a nasal spray has already been proven safe and effective in viral respiratory infections. We explored this antiviral activity in Calu-3, a human respiratory model cell line. A formula of iota-carrageenan and sodium chloride, as a nasal spray, already approved for human use, effectively inhibited SARS-CoV-2 infection in vitro, providing a more substantial reference for further clinical studies or developments.

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Varese, A., Ceballos, A., Palacios, C. A., Figueroa, J. M., Dugour, A. V.. 2021-04-27. Iota-carrageenan prevents the replication of SARS-CoV-2 on an in vitro respiratory epithelium model. https://doi.org/10.1101/2021.04.27.441512

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