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bioRxiv · 10.1101/2021.04.26.441457

Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the UK B.1.1.7 and SA B.1.351 variant

Weiss, A.·Touret, F.·Baronti, C.·Gilles, M.·Hoen, B.·Nougairede, A.·de Lamballerie, X.·Sommer, M. O. A.
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Abstract

SARS-CoV-2 variants are emerging with potential increased transmissibility highlighting the great unmet medical need for new therapies. Niclosamide is a potent anti-SARS-CoV-2 agent that has advanced in clinical development. We validate the potent antiviral efficacy of niclosamide in a SARS-CoV-2 human airway model. Furthermore, niclosamide is effective against the D614G, B.1.1.7 and B.1.351 variants. Our data further support the potent anti-SARS-CoV-2 properties of niclosamide and highlights its great potential as a therapeutic agent for COVID-19.

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Weiss, A., Touret, F., Baronti, C., Gilles, M., Hoen, B., Nougairede, A., de Lamballerie, X., Sommer, M. O. A.. 2021-04-26. Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the UK B.1.1.7 and SA B.1.351 variant. https://doi.org/10.1101/2021.04.26.441457

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