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bioRxiv · 10.1101/2021.03.28.437305

Associations Between Task-Related Modulation of Motor-Evoked Potentials and EEG Event-Related Desynchronization in Children with ADHD

Ewen, J. B.·Puts, N. A.·Mostofsky, S. H.·Horn, P. S.·Gilbert, D. L.
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Abstract

Children with attention-deficit/hyperactivity disorder (ADHD) have previously shown a decreased magnitude of event-related desynchronization (ERD) during a finger-tapping task, with a large between-group effect. Because the neurobiology underlying several TMS measures have been studied in multiple contexts, we compared ERD and three TMS measures (Resting Motor Threshold [RMT], Short-Interval Cortical Inhibition [SICI] and Task-Related Up-Modulation [TRUM]) within 14 participants with ADHD (ages 8-12y) and 17 control children. The TD group showed a correlation between greater RMT and greater magnitude of alpha (10-13Hz, here) ERD, and there was no diagnostic interaction effect, consistent with a rudimentary model of greater needed energy input to stimulate movement. Similarly, inhibition measured by SICI was also greater in the TD group when the magnitude of movement-related ERD was higher; there was a miniscule diagnostic interaction effect. Finally, TRUM during a response-inhibition task showed an unanticipated pattern: in TD children, the greater TMS task modulation (TRUM) was associated with a smaller magnitude of ERD during finger-tapping. The ADHD group showed the opposite direction of association: greater TRUM was associated with larger-magnitude ERD. Prior EEG results have demonstrated specific alterations of task-related modulation of cortical physiology, and the current results provide a fulcrum for multimodal study.

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Ewen, J. B., Puts, N. A., Mostofsky, S. H., Horn, P. S., Gilbert, D. L.. 2021-03-29. Associations Between Task-Related Modulation of Motor-Evoked Potentials and EEG Event-Related Desynchronization in Children with ADHD. https://doi.org/10.1101/2021.03.28.437305

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