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bioRxiv · 10.1101/2021.03.06.434210

Sleep deprivation exacerbates seizures and diminishes GABAergic tonic inhibition

Kondru, S. S.·Pan, Y.·Wallace, E. P.·Pfammatter, J.·Jones, M. V.·Maganti, R.
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Abstract

Patients with epilepsy report that sleep deprivation is a common trigger for breakthrough seizures. The basic mechanism of this phenomenon is unknown. In the Kv1.1-/- mouse model of epilepsy, daily sleep deprivation indeed exacerbated seizures though these effects were lost after the 3rd day. Sleep deprivation also accelerated mortality in ~52% of Kv1.1-/- mice, not observed in controls. Voltage-clamp experiments on the day after recovery from sleep deprivation showed reductions in GABAergic tonic inhibition in dentate granule cells both in Kv1.1-/- and wild-type mice. Our results suggest that sleep deprivation is detrimental to seizures and survival, possibly due to reductions in GABAergic tonic inhibition.

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Kondru, S. S., Pan, Y., Wallace, E. P., Pfammatter, J., Jones, M. V., Maganti, R.. 2021-03-08. Sleep deprivation exacerbates seizures and diminishes GABAergic tonic inhibition. https://doi.org/10.1101/2021.03.06.434210

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